Recognizing Post-Exertional Malaise: When “No Pain, No Gain” Backfires

You know that satisfying ache after a tough workout? That little signal that tells you you've pushed yourself? For many, it’s a sign of growth and progress. 

But for people with conditions like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), pushing through exertion doesn’t lead to strength or endurance. It leads to something far more debilitating: post-exertional malaise (PEM).

PEM isn’t just about feeling tired. It’s a deep, system-wide crash triggered by physical, mental, or emotional exertion. And it can last for days, or even weeks! 

While most people recover after rest, those with PEM don’t bounce back so easily. If you live with post-exertional malaise or treat patients with chronic fatigue, understanding this phenomenon is critical to spot the signs and better manage your energy.

The Desire to Push vs. The Reality of PEM

Our culture glorifies pushing limits. "No pain, no gain" is the mantra of athletes, trainers, and everyday fitness enthusiasts. When a group of exercisers talks about the soreness they feel after a workout, they frame it as a badge of honor, like evidence of hard work paying off. It’s a mindset that equates discomfort with growth, and fatigue with progress.

I’ve seen this firsthand. I recently joined a strength training group, hoping to build some resilience. As we finished a session, the conversation turned to muscle soreness. The others talked about how they liked feeling a little sore afterward. It meant they pushed themselves! And I understood that. That desire to test limits and to push past what we thought was possible is deeply ingrained in us.

But for people with chronic fatigue, the instinct to push can lead to devastating consequences. 

Before I was diagnosed with ME/CFS, I would intensely exercise, hoping I’d regain energy. I pushed myself through my discomfort like I did when I was younger. I’d tell myself mantras like, Your body is stronger than your mind thinks it is! 

But mental fortitude can’t always overcome the effects of a chronic condition. And I’d pay the price by being bedridden the next day. A simple workout had triggered an overpowering crash, complete with muscle pain, brain fog, and flu-like exhaustion.

The problem starts when doctors, trainers, or even well-meaning friends assume that pushing through fatigue is universally beneficial. It’s not. 

For someone with PEM, exertion isn’t a thing to be powered through. It’s something to regulate with care.

Fatigue vs. Exertion Intolerance: Why Words Matter

One of the biggest misunderstandings about ME/CFS is that it’s just "chronic fatigue." But fatigue is only part of the story. A more accurate but lesser-known name for the condition is Systemic Exertion Intolerance Disease (SEID). This name captures the real issue: exertion intolerance.

PEM isn’t the same as feeling wiped out after a long day. It’s a delayed, disproportionate response to effort that can leave someone bedridden after something as simple as taking a shower. 

This distinction is more important than you know. It shapes how patients and medical professionals approach treatment. If the focus is solely on "fatigue," it invites strategies that don’t work, or can even cause harm.

Dr. Charles Shepherd, Medical Adviser to the ME Association, speaks to the consequences of exceeding our physical or mental or physical limitations

"If patients exceed their very limited limitations, in relation to physical activity or mental activity, they pay for that and they get this post-exertion exacerbation of these symptoms."

Diagnostic Red-Flags Doctors Should Spot

When a patient walks into a doctor’s office complaining of extreme fatigue, the response is often predictable: "Get some rest and try to stay active." But that assumes that fatigue is the problem, not a symptom of something deeper.

If a patient reports worsening symptoms after exertion, that should raise immediate concern. Medical professionals should pause and embrace uncertainty before prescribing exercise or lifestyle changes that emphasize pushing through discomfort.  

Instead, track what happens in the hours or days following the activity. 

  • Does a short walk lead to flu-like symptoms? 

  • Does mental effort trigger a full-body shutdown? 

These aren’t signs of deconditioning. They’re hallmarks of PEM.

A simple yet effective tool for tracking PEM is the 2-day cardiopulmonary exercise test (CPET), which has shown that people with ME/CFS experience a significant drop in function on the second day of testing. This is something that doesn’t happen in PEM-free individuals.

While not always practical for diagnosis, the CPET can emphasize what patients already know: exertion isn’t just tiring–it’s damaging.

💡Here’s a handy toolkit for helping your patients manage post-exertional malaise →

Managing PEM: Basic Strategies for Patients and Caregivers

Since PEM isn’t something that can be trained away, managing it requires a radical shift in thinking. 

In previous blogs, I’ve discussed various chronic illness management strategies, including The Midnight Effect model. 

But an absolute-must foundational strategy is known as pacing.

Pacing is an energy management method that prioritizes avoiding overexertion before symptoms escalate.

It’s not about avoiding activity altogether. It’s about finding a sustainable balance. With pacing, you’re encouraged to respect your body’s limits even when you feel “fine,” because you know the consequences of overdoing it won’t be instant.

Try some of these basic pacing techniques and see which ones help:

  1. The Energy Envelope

Think of your energy as a cash budget: you can only spend what you actually have (there’s no swiping your credit card here!). 

Identify the level of activity that’s led to your post-exertional malaise in the past, and aim to stay within or just below that limit to avoid crashes. 

Tracking symptoms and daily activities can help you pinpoint where your personal “energy ceiling” is. This is different for everyone.

2. The 50% Rule 

If you feel like you can handle a certain level of activity, do only half of it. This helps prevent the common trap of overestimating your capacity, and paying for it later. 

The 50% rule is especially useful on days when you feel better. Why? Oftentimes, PEM results from pushing too hard when symptoms temporarily improve and we’re feeling good

3. Heart Rate Monitoring 

Physical exertion can trigger PEM when it exceeds the anaerobic threshold (the point where the body switches from aerobic to anaerobic metabolism). 

Using a heart rate monitor to stay within a safe range (usually keeping your heart rate below 50-60% of your estimated maximum) can help prevent post-exertional crashes.

4. Preemptive Resting

Instead of waiting until you feel exhausted, schedule regular breaks throughout the day. Resting before fatigue sets in can reduce your exhaustion and help maintain a more consistent level of function. This might involve lying down, meditating, or simply closing your eyes in a quiet room for a few minutes.

Are you a loved one or caregiver for someone with long COVID or ME/CFS? An excellent way to support them is simply to validate their experience and support them in implementing these techniques. If you’re worried you’re not truly helping them, remember this: encouraging rest isn’t enabling weakness. It’s allowing them to maintain function.

💡Want more PEM tactics? Explore this resource guide → 

Final Thoughts: Shifting the Exertion Narrative

One of the biggest challenges for people with PEM isn’t just the condition itself. It’s the misunderstandings they face. Friends, family, and even doctors often misinterpret the symptoms, assuming these individuals are out of shape, unmotivated, or exaggerating. 

But PEM goes far beyond willpower. It’s a physiological response driven by dysfunctions in the immune, nervous, and metabolic systems.

Dr. Paul Cheney, CFS researcher and clinician, points out this distinction:

“The whole idea that you can take a disease like this and exercise your way to health is foolishness. It is insane.” 

Despite growing research, these outdated assumptions persist. This is why language matters. When PEM is dismissed as “just being tired,” patients are left without the support they need.

For anyone living with ME/CFS, validation is a form of care. These people need to respect the boundaries of their own bodies to function and live a good life. 

Instead of asking, Why can’t they just push through?, we should be asking: What happens when exertion makes someone sicker?

Because for some, pushing doesn’t mean progress. It means an impending setback.


By the way–I discuss these topics and more in my seminars, keynote talks, and university classroom visits. If you’re looking for someone to shed light on the realities of this condition, reach out to me here.

Previous
Previous

4 Stages of Illness Identity: How to Find Yourself Again

Next
Next

What is the Midnight Effect? A Metaphor to Help Manage Chronic Illness